Yan, H;
Nazaretski, E;
Lauer, K;
Huang, X;
Wagner, U;
Rau, C;
Yusuf, M;
... Chu, YS; + view all
(2016)
Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution.
Scientific Reports
, 6
, Article 20112. 10.1038/srep20112.
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Abstract
We developed a scanning hard x-ray microscope using a new class of x-ray nano-focusing optic called a multilayer Laue lens and imaged a chromosome with nanoscale spatial resolution. The combination of the hard x-ray's superior penetration power, high sensitivity to elemental composition, high spatial-resolution and quantitative analysis creates a unique tool with capabilities that other microscopy techniques cannot provide. Using this microscope, we simultaneously obtained absorption-, phase-, and fluorescence-contrast images of Pt-stained human chromosome samples. The high spatial-resolution of the microscope and its multi-modality imaging capabilities enabled us to observe the internal ultra-structures of a thick chromosome without sectioning it.
| Type: | Article |
|---|---|
| Title: | Multimodality hard-x-ray imaging of a chromosome with nanoscale spatial resolution |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/srep20112 |
| Publisher version: | http://www.nature.com/srep/2016/160205/srep20112/f... |
| Language: | English |
| Additional information: | Copyright © The Authors. Published by Nature Publishing Group (NPG). This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1493304 |
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