Rodrigues, S; Desroches, M; Krupa, M; Cortes, JM; Sejnowski, TJ; Ali, AB; (2016) Time-coded neurotransmitter release at excitatory and inhibitory synapses. Proceedings of the National Academy of Sciences , 113 (8) E1108-E1115. 10.1073/pnas.1525591113.

Preview

Text Rodrigues_etal_pnas 2016 author version.pdf - Accepted Version Download (1MB) | Preview

Abstract

Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs. Neurotransmitter can also be released asynchronously, that is, after a delay following the spike, or spontaneously in the absence of a stimulus. The mechanisms underlying asynchronous and spontaneous neurotransmitter release remain elusive. Here, we describe a model of the exocytotic cycle of vesicles at excitatory and inhibitory synapses that accounts for all modes of vesicle release as well as short-term synaptic plasticity (STSP). For asynchronous release, the model predicts a delayed inertial protein unbinding associated with the SNARE complex assembly immediately after vesicle priming. Experiments are proposed to test the model's molecular predictions for differential exocytosis. The simplicity of the model will also facilitate large-scale simulations of neural circuits.

Download activity - last month

Export as CSVJSONXML

Download activity - last 12 months

Export as CSVJSONXML

Downloads by country - last 12 months

Export as JSONCSVXML

Archive Staff Only

View Item