Silveira, A;
McLeod, O;
Strawbridge, RJ;
Gertow, K;
Sennblad, B;
Baldassarre, D;
Veglia, F;
... Hamsten, A; + view all
(2015)
Plasma IL-5 concentration and subclinical carotid atherosclerosis.
Atherosclerosis
, 239
(1)
pp. 125-130.
10.1016/j.atherosclerosis.2014.12.046.
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Abstract
OBJECTIVE: Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT). METHODS: We used biobank and databases of IMPROVE, a large European prospective cohort study of high-risk individuals (n = 3534) free of clinically overt cardiovascular disease at enrollment, in whom composite and segment-specific measures of cIMT were recorded at baseline and after 15 and 30 months. IL-5 was measured with an immunoassay in plasma samples taken at baseline. RESULTS: IL-5 levels were lower in women than in men, lower in the South than in North of Europe, and showed positive correlations with most established risk factors. IL-5 showed significant inverse relationships with cIMT change over time in the common carotid segment in women, but no significant relationships to baseline cIMT in either men or women. CONCLUSIONS: Our results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women. However, the relationships are weak and whereas IL-5 has been proposed as a potential molecular target to treat allergies, it is difficult to envisage such a scenario in coronary artery disease.
| Type: | Article |
|---|---|
| Title: | Plasma IL-5 concentration and subclinical carotid atherosclerosis |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.atherosclerosis.2014.12.046 |
| Publisher version: | http://dx.doi.org/10.1016/j.atherosclerosis.2014.1... |
| Language: | English |
| Additional information: | © 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Atherosclerosis, Coronary artery disease, Cytokines, Interleukin-5, Intima-media thickness, Aged, Anthropometry, Biological Specimen Banks, Biomarkers, Carotid Arteries, Carotid Artery Diseases, Carotid Intima-Media Thickness, Disease Progression, Europe, Female, Genetic Variation, Humans, Immunoassay, Interleukin-5, Male, Middle Aged, Prospective Studies, Regression Analysis, Sex Factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1461267 |
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