Wornham, DP;
Hajjawi, MO;
Orriss, IR;
Arnett, TR;
(2014)
Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures.
Osteoporos Int
, 25
(10)
2477 - 2484.
10.1007/s00198-014-2791-5.
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Abstract
The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells. These results suggest that strontium treatment could have previously overlooked effects on bone.
| Type: | Article |
|---|---|
| Title: | Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00198-014-2791-5 |
| Publisher version: | http://dx.doi.org/10.1007/s00198-014-2791-5 |
| Language: | English |
| Additional information: | © The Author(s) 2014. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1436190 |
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