Phillips, JB;
(2014)
Building stable anisotropic tissues using cellular collagen gels.
Organogenesis
, 10
(1)
pp. 6-8.
10.4161/org.27487.
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Abstract
Combining cellular self-alignment within tethered collagen gels with stabilization through subsequent removal of interstitial fluid has yielded a new process for the fabrication of aligned cellular biomaterials. This commentary discusses the generation of engineered neural tissue for peripheral nerve repair using this combination of techniques, providing additional insight into the rationale underpinning the approach. By describing the potential benefits of using cell and matrix interactions to organize 3D hydrogels that can be stabilized to form tissue-like constructs, the article aims to highlight the potential for the approach to be used in the generation of a wider range of functional replacement tissues.
| Type: | Article |
|---|---|
| Title: | Building stable anisotropic tissues using cellular collagen gels |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4161/org.27487 |
| Publisher version: | http://dx.doi.org/10.4161/org.27487 |
| Additional information: | © 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1421317 |
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