Gomes-Santos, CS;
Itoe, MA;
Afonso, C;
Henriques, R;
Gardner, R;
Sepúlveda, N;
Simões, PD;
... Mota, MM; + view all
(2012)
Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes.
PLoS One
, 7
(1)
, Article e29408. 10.1371/journal.pone.0029408.
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Abstract
Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing Plasmodium berghei parasites inside human hepatoma cells. Actin reorganization is most prominent between 10 to 16 hours post infection and depends on the actin severing and capping protein, gelsolin. Live cell imaging studies also suggest that the hepatocyte cytoskeleton may contribute to parasite elimination during Plasmodium development in the liver.
| Type: | Article |
|---|---|
| Title: | Highly Dynamic Host Actin Reorganization around Developing Plasmodium Inside Hepatocytes |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0029408 |
| Publisher version: | http://dx.doi.org/10.1371/10.1371/journal.pone.002... |
| Language: | English |
| Additional information: | © 2012 Gomes-Santos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. PMCID: PMC3253080 |
| Keywords: | Actin Cytoskeleton, Actins, Animals, Cells, Cultured, Gelsolin, Green Fluorescent Proteins, Hepatocytes, Host-Parasite Interactions, Humans, Kinetics, Liver, Mice, Mice, Inbred BALB C, Organisms, Genetically Modified, Plasmodium, Protein Multimerization, Tubulin |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1411119 |
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