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Influence of single nucleotide polymorphisms in COMT, MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease

Cheshire, P; Bertram, K; Ling, H; O'Sullivan, SS; Halliday, G; McLean, C; Bras, J; ... Williams, DR; + view all (2014) Influence of single nucleotide polymorphisms in COMT, MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease. Neurodegenerative Diseases , 13 (1) pp. 24-28. 10.1159/000351097. Green open access

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Abstract

Clinical heterogeneity in the development of levodopa-induced dyskinesias (LID) suggests endogenous factors play a significant role in determining their overall prevalence.

Type: Article
Title: Influence of single nucleotide polymorphisms in COMT, MAO-A and BDNF genes on dyskinesias and levodopa use in Parkinson's disease
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000351097
Publisher version: http://dx.doi.org/10.1159/000351097
Language: English
Additional information: Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Keywords: Aged, Antiparkinson Agents, Brain-Derived Neurotrophic Factor, Catechol O-Methyltransferase, Cohort Studies, Dyskinesia, Drug-Induced, Female, Humans, Levodopa, Male, Middle Aged, Monoamine Oxidase, Parkinson Disease, Polymorphism, Single Nucleotide, Prevalence, Time Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1405031
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