Liang, Y; Gordon, E; Rohrer, J; Downey, L; de Silva, R; Jäger, HR; Nicholas, J; ... Caine, D; + view all Liang, Y; Gordon, E; Rohrer, J; Downey, L; de Silva, R; Jäger, HR; Nicholas, J; Modat, M; Cardoso, MJ; Mahoney, C; Warren, J; Rossor, M; Fox, N; Caine, D; - view fewer (2013) A cognitive chameleon: Lessons from a novel MAPT mutation case. Neurocase 10.1080/13554794.2013.826697.

Preview

PDF 10.1080-13554794.2013.826697.pdf Download (378kB)

Abstract

We report a case of frontotemporal dementia caused by a novel MAPT mutation (Q351R) with a remarkably long amnestic presentation mimicking familial Alzheimer's disease. Longitudinal clinical, neuropsychological and imaging data provide convergent evidence for predominantly bilateral anterior medial temporal lobe involvement consistent with previously established neuroanatomical signatures of MAPT mutations. This case supports the notion that the neural network affected in MAPT mutations is determined to a large extent by the underlying molecular pathology. We discuss the diagnostic significance of anomia in the context of atypical amnesia and the impact of impaired episodic and semantic memory systems on autobiographical memory.

Download activity - last month

Export as CSVXMLJSON

Download activity - last 12 months

Export as CSVXMLJSON

Downloads by country - last 12 months

Export as JSONCSVXML

Archive Staff Only

View Item