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Spatial and episodic memory tasks promote temporal lobe interictal spikes

Vivekananda, U; Bush, D; Bisby, JA; Diehl, B; Jha, A; Nachev, P; Rodionov, R; ... Walker, MC; + view all (2019) Spatial and episodic memory tasks promote temporal lobe interictal spikes. Annals of Neurology 10.1002/ana.25519. (In press). Green open access

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Abstract

Reflex epilepsies have been demonstrated to exploit specific networks that subserve normal physiological function. It is unclear whether more common forms of epilepsy share this particular feature. By measuring interictal spikes in patients with a range of epilepsies, we show that two tasks known to specifically engage the hippocampus and temporal neocortex promote increased interictal spiking within these regions, whilst a non‐hippocampal dependent task did not. This indicates that interictal spike frequency may reflect the processing demands being placed on specific functional‐anatomical networks in epilepsy.

Type: Article
Title: Spatial and episodic memory tasks promote temporal lobe interictal spikes
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ana.25519
Publisher version: https://doi.org/10.1002/ana.25519
Language: English
Additional information: Copyright © 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/10075851
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