UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility

Hosking, A; Koulouroudias, M; Zemrak, F; Moon, JC; Rossi, A; Lee, A; Barnes, MR; ... Petersen, SE; + view all (2016) Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility. European Heart Journal - Cardiovascular Imaging , 18 (11) pp. 1216-1221. 10.1093/ehjci/jew205. Green open access

[thumbnail of Petersen Evaluation of splenic switch off 2016 Accepted.pdf]
Preview
Text
Petersen Evaluation of splenic switch off 2016 Accepted.pdf - Accepted Version

Download (6MB) | Preview

Abstract

Aims Adenosine can induce splenic vasoconstriction (splenic switch-off, SSO). In this study, we aim to evaluate the utility of identifying a lack of SSO for detecting false-negative adenosine stress perfusion cardiac magnetic resonance (CMR) scans. Methods and results We visually analysed 492 adenosine stress perfusion CMR scans reported as negative in a cohort of patients with no previous history of coronary artery disease. A lack of SSO was identified in 11%. We quantified the phenomenon by drawing regions of interest on the spleen and comparing intensity between stress and rest scans, the spleen intensity ratio (SIR). Inter-rater agreement for qualitative determination of SSO was κ = 0.81 and inter-class correlation for quantitative determination of SSO was 0.94. The optimal threshold for SIR as an indicator of SSO was 0.40 (sensitivity = 82.5%, specificity = 92.3%, AUC = 0.91). 23 065 CMR scans and 9926 invasive coronary angiogram reports were retrospectively examined to identify patients with negative CMR scans who required coronary intervention in the subsequent 12 months (false negatives). We compared these scans with true positives who had positive adenosine stress perfusion CMR scans followed by coronary intervention. The rate of lack of SSO was 20.7% in the false-negative group versus 13.1% in true positives (P = 0.37). Conclusion The lack of SSO is prevalent, easily measureable, and has potential to improve on haemodynamic criteria as a marker of adenosine understress in CMR perfusion scans.

Type: Article
Title: Evaluation of splenic switch off in a tertiary imaging centre: validation and assessment of utility
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ehjci/jew205
Publisher version: https://doi.org/10.1093/ehjci/jew205
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Radiology, Nuclear Medicine & Medical Imaging, Cardiovascular System & Cardiology, Stress CMR, Splenic switch-off, Adenosine, Cardiac magnetic resonance, CARDIAC MAGNETIC-RESONANCE, CORONARY-ARTERY-DISEASE, MYOCARDIAL-PERFUSION, PROGNOSTIC VALUE, ADENOSINE, METAANALYSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10065511
Downloads since deposit
85Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item