McGranahan, N;
Swanton, C;
(2017)
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.
Cell
, 168
(4)
pp. 613-628.
10.1016/j.cell.2017.01.018.
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Abstract
Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent to tumor evolution. We emphasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alterations, in driving tumor evolution and metastasis and consider the role of the tumor microenvironment in engendering heterogeneity and drug resistance. We suggest that bold approaches to drug development, harnessing the adaptive properties of the immune-microenvironment while limiting those of the tumor, combined with advances in clinical trial-design, will improve patient outcome.
| Type: | Article |
|---|---|
| Title: | Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cell.2017.01.018 |
| Publisher version: | http://dx.doi.org/10.1016/j.cell.2017.01.018 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, CELL LUNG-CANCER, POTENTIAL THERAPEUTIC TARGETS, CHRONIC LYMPHOCYTIC-LEUKEMIA, METASTATIC PROSTATE-CANCER, PAIRED EXOME ANALYSIS, BREAST-CANCER, ESOPHAGEAL ADENOCARCINOMA, MUTATIONAL PROCESSES, COLORECTAL-CANCER, COPY NUMBER |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10046495 |
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