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Phylogenomic analysis of natural selection pressure in Streptococcus genomes

Anisimova, M; Bielawski, J; Dunn, K; Yang, Z; (2007) Phylogenomic analysis of natural selection pressure in Streptococcus genomes. BMC Evolutionary Biology , 7 (August) , Article 154. 10.1186/1471-2148-7-154. Green open access

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Abstract

In comparative analyses of bacterial pathogens, it has been common practice to discriminate between two types of genes: (i) those shared by pathogens and their non-pathogenic relatives (core genes), and (ii) those found exclusively in pathogens (pathogen-specific accessory genes). Rather than attempting to a priori delineate genes into sets more or less relevant to pathogenicity, we took a broad approach to the analysis of Streptococcus species by investigating the strength of natural selection in all clusters of homologous genes. The genus Streptococcus is comprised of a wide variety of both pathogenic and commensal lineages, and we relate our findings to the pre-existing knowledge of Streptococcus virulence factors.

Type: Article
Title: Phylogenomic analysis of natural selection pressure in Streptococcus genomes
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2148-7-154
Publisher version: http://dx.doi.org/10.1186/1471-2148-7-154
Language: English
Additional information: PMCID: PMC2031904 © 2007 Anisimova et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Biological Evolution, Gene Expression Regulation, Bacterial, Genome, Bacterial, Multigene Family, Phylogeny, Selection, Genetic, Streptococcus, Virulence
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/99942
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