STEPHANOU, A; SARLIS, NJ; KNIGHT, RA; LIGHTMAN, SL; CHOWDREY, HS; (1992) EFFECTS OF CYCLOSPORINE-A ON THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ANTERIOR-PITUITARY INTERLEUKIN-6 MESSENGER-RNA EXPRESSION DURING CHRONIC INFLAMMATORY STRESS IN THE RAT. J NEUROIMMUNOL , 41 (2) 215 - 222.
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In the rat, adjuvant arthritis (AA) is an inflammatory joint disease associated with chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis. We have investigated the effects of the immunosuppressive agent cyclosporine A (CsA) on plasma levels of adrenocorticotropin (ACTH) and corticosterone (B), as well as on anterior pituitary proopiomelanocortin (POMC) and interleukin (IL)-6 mRNA accumulation in control and adjuvant-injected animals. In control animals, CsA reduced basal anterior pituitary POMC and IL-6 mRNA and decreased plasma levels of ACTH and B. Adjuvant-injected animals that were treated with CsA showed no clinical signs of AA. Moreover, CsA inhibited the arthritis-induced increases in pituitary POMC and IL-6 mRNA levels and in circulating ACTH and B. In vitro, CsA reduced the POMC mRNA content of cultured anterior pituitary cells and diminished the stimulatory effects of corticotropin-releasing hormone (CRH) on POMC mRNA expression and ACTH secretion from these cells. These data indicate that CsA has a direct action on the HPA axis and also reduces the activation of the HPA axis seen in chronic inflammatory arthritis.
|Title:||EFFECTS OF CYCLOSPORINE-A ON THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND ANTERIOR-PITUITARY INTERLEUKIN-6 MESSENGER-RNA EXPRESSION DURING CHRONIC INFLAMMATORY STRESS IN THE RAT|
|Keywords:||ADRENOCORTICOTROPIN, ADJUVANT ARTHRITIS, CORTICOSTERONE, CYCLOSPORINE-A, INTERLEUKIN-6, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, CORTICOTROPIN-RELEASING-FACTOR, CELLS-INVITRO, RHEUMATOID-ARTHRITIS, TISSUE DISTRIBUTION, GENE-EXPRESSION, LYMPHOCYTES-T, LEWIS RAT, RESPONSES, MECHANISM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Genes, Development and Disease > ICH - Medical Molecular Biology Unit|
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