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Endothelial response to childhood infection: The role of mannose-binding lectin (MBL)

Charakida, M; Donald, AE; Leary, S; Halcox, JP; Turner, MW; Johnson, M; Loukogeorgakis, SP; ... Klein, NJ; + view all (2010) Endothelial response to childhood infection: The role of mannose-binding lectin (MBL). ATHEROSCLEROSIS , 208 (1) 217 - 221. 10.1016/j.atherosclerosis.2009.07.055.

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Abstract

Objective: To assess the influence of mannose-binding lectin (MBL) genotype on endothelial function in the presence and absence of infection in childhood.Methods: We studied 2176 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children. Endothelial function was assessed by flow mediated dilatation (FMD). Exon 1 and promoter polymorphisms in the MBL gene were determined by heteroduplexing procedures. Children were classified as AA (wild type) AO (heterozygotes) and OO (homozygotes).Results: During the vascular assessment, 544 children presented with current or recent (<2 weeks) infection (INF). FMD was reduced in the INF group compared to controls (10% reduction in FMD, p < 0.001). MBL genotype was not associated with FMD in controls, although a relationship with the degree of impairment during INF was observed (8.0%, 7.6% and 26.6% lower FMD compared to controls for groups AA, AO, OO respectively, p < 0.05). After multivariate analysis, OO was associated with reduced FMD in the INF group (odds ratio 2.95 [1.33, 6.52], p < 0.001).Conclusion: Homozygosity for MBL variant alleles is associated with greater impairment in FMD during infection in childhood. This suggests a gene-environment interaction operating in early life that may have relevance for the initiation and progression of atherosclerosis. (c) 2009 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Endothelial response to childhood infection: The role of mannose-binding lectin (MBL)
DOI: 10.1016/j.atherosclerosis.2009.07.055
Keywords: Complement, Endothelium, Children, Genes, Mannose-binding lectin, CORONARY-ARTERY-DISEASE, NEISSERIA-MENINGITIDIS, INFLAMMATORY RESPONSE, VARIANT ALLELES, ASSOCIATION, ATHEROSCLEROSIS, DYSFUNCTION, RISK, DEFICIENCY, MECHANISMS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Infect, Imm, Infla. and Physio Med
URI: http://discovery.ucl.ac.uk/id/eprint/99023
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