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Ion-Specific Effects on the Interaction between Fibronectin and Negatively Charged Mica Surfaces

Heath, MD; Henderson, B; Perkin, S; (2010) Ion-Specific Effects on the Interaction between Fibronectin and Negatively Charged Mica Surfaces. LANGMUIR , 26 (8) 5304 - 5308. 10.1021/la100678n.

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Abstract

Atomic force microscopy (A FM) imaging and subsequent image analysis have been used to measure the ion-specific and ionic strength elects on the adsorption of fibronectin to mica surfaces in buffer solution. Increasing the concentration of monovalent Na+ salt solutions is shown to cause a transition from tightly aggregated and "string-of-heads" structures on the mica surface to well dispersed single-molccule adsorption. Studying the effect of two divalent salts. Ni2- and Ca2+, reveals a dramatic enhancement of fibronectin adsorption to mica in hurler solutions containing Ni2+, hut not for Ca2+. The origin of this ion-specific effect is discussed.

Type:Article
Title:Ion-Specific Effects on the Interaction between Fibronectin and Negatively Charged Mica Surfaces
DOI:10.1021/la100678n
Keywords:ATOMIC-FORCE MICROSCOPY, ELECTRON-MICROSCOPY, STRENGTH, MATRIX, PH, CONFORMATIONS, ADSORPTION, INTEGRINS, PROTEINS, MOLECULE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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