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Resuscitation-promoting factors possess a lysozyme-like domain

Cohen-Gonsaud, M; Keep, NH; Davies, AP; Ward, J; Henderson, B; Labesse, G; (2004) Resuscitation-promoting factors possess a lysozyme-like domain. TRENDS BIOCHEM SCI , 29 (1) 7 - 10. 10.1016/j.tibs.2003.10.009.

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Abstract

The novel bacterial cytokine family - resuscitation-promoting factors (Rpfs) - share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.

Type:Article
Title:Resuscitation-promoting factors possess a lysozyme-like domain
DOI:10.1016/j.tibs.2003.10.009
Keywords:AUTOCRINE GROWTH-FACTORS, EGG-WHITE LYSOZYME, MYCOBACTERIUM-TUBERCULOSIS, RECOGNITION, PREDICTION, PROFILES, PROTEINS, DATABASE, MODELS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering

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