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Temporal properties of cerebellar-dependent memory consolidation

Cooke, SF; Attwell, PJE; Yeo, CH; (2004) Temporal properties of cerebellar-dependent memory consolidation. J NEUROSCI , 24 (12) 2934 - 2941. 10.1523/JNEUROSCI.5505-03.2004. Green open access

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Abstract

Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible inactivations of the cerebellar cortex, but not of the cerebellar nuclei, with the GABA(A) receptor agonist muscimol. Here, the temporal properties of this cerebellar cortex-dependent consolidation were examined using delayed infusions of muscimol in cortical lobule HVI. Cortical infusions delayed by 5 or 45 min after a conditioning session produced significant and very similar impairments of consolidation, but infusions delayed by 90 min produced little or no impairment. Behavioral measures indicate that the muscimol infusions produced significant effects after similar to30 min and they lasted for a few hours. So, over a time window beginning similar to1 hr after the end of the training session and closing 1 hr after that, intracortical activity is critical for consolidation of this motor memory.

Type: Article
Title: Temporal properties of cerebellar-dependent memory consolidation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.5505-03.2004
Keywords: motor learning, consolidation, classical conditioning, nictitating membrane, muscimol, olivo-cortico-nuclear loop, time window, CONDITIONED EYELID RESPONSES, FLOCCULUS TARGET NEURONS, NICTITATING-MEMBRANE, SQUIRREL-MONKEY, PROTEIN-KINASE, MOTOR MEMORY, ACQUISITION, INACTIVATION, EXTINCTION, PLASTICITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/9817
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