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Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus

Bullmann, T; de Silva, R; Holzer, M; Mori, H; Arendt, T; (2007) Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus. HIPPOCAMPUS , 17 (2) 98 - 102. 10.1002/hipo.20255.

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Abstract

Tau is a microtubule-associated protein with a developmentally regulated expression of multiple isoforms. The neonatal isoform is devoid of two amino terminal inserts and contains only three instead of four microtubuie-binding repeats (0N/3R-tau). We investigated the temporal expression pattern of 0N-tau and 3R-tau in the rat hippocampus. After the decline of 0N-tau and 3R-tau immunoreactivity during the postnatal development both isoforms remain highly expressed in a few cells residing beneath the granule cell layer. Coexpression of the polysialylated neuronal cell adhesion molecule, doublecortin, and incorporated bromode-oxyuridine showed that these cells are proliferating progenitor cells. in contrast mature granule cells express the adult tau protein isoform containing one aminoterminal insert domain (1N-tau). Therefore a shift in tau isoform expression takes place during adult neurogenesis, which might be related to migration, differentiation, and integration in the granule cell layer. A model for studying shifts in tau isoform expression in a defined subset of neurons might help to understand the etiology of tauopathies, when isoform composition is crucial for neurodegeneration, as in Pick's disease or FTDP-17. (c) 2006 Wiley-Liss, Inc.

Type: Article
Title: Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus
DOI: 10.1002/hipo.20255
Keywords: development, neuronal differentiation, neuronal plasticity, hippocampus, neurodegeneration, MOLECULE NCAM-H, MICROTUBULE-BINDING, THYROID-HORMONE, DENTATE GYRUS, NERVOUS-SYSTEM, PICKS-DISEASE, GERMINAL ZONE, RAT, BRAIN, CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/98018
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