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Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus

Wootton, PTE; Stephens, JW; Hurel, SJ; Durand, H; Cooper, J; Ninio, E; ... Talmud, PJ; + view all (2006) Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus. ATHEROSCLEROSIS , 189 (1) 149 - 156. 10.1016/j.atherosclerosis.2005.12.009.

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Abstract

Lipoprotein associated phospholipase A2 (Lp-PLA2) modulates low-density lipoprotein (LDL) oxidation by hydrolysing oxidised phospholipids present on particle surfaces. We investigated whether Lp-PLA2 activity and PLA2G7 A379V genotype were related to mediators of atherosclerosis in a diabetic study. Plasma Lp-PLA2 activity (taken in men only) and A379V genotype were investigated with regards to metabolic syndrome (MS), UKPDS risk score, and oxidised LDL (oxLDL/LDL), in a cohort of Caucasian men and women (n = 783, age 62.5 +/- 13.7 years). After adjustment for type of diabetes, CHID status, and statin use, those individuals with features defining the MS (WHO guidelines) had higher Lp-PLA2 activity (35.6 +/- 11.9 nmol/min/ml) compared to those without (33.0 +/- 10.8 nmol/min/ml) (p = 0.02). Quartiles of UKPDS coronary heart disease (CHD) risk score were also positively associated with Lp-PLA2 activity (p = 0.006, p = 0.004 linear trend). Those men in the highest quartile of oxLDL/LDL level had the lowest Lp-PLA2 activity (31.3 +/- 10.5 nmol/min/ml) when compared to the middle two (32.3 +/- 9.8 and 35.9 +/- 110.9 nmol/min/ml, respectively) and lowest quartile (35.6 +/- 12.5 nmol/min/ml; p = 0.03, p = 0.004 linear trend). There was no significant association between A379V genotype and Lp-PLA2 enzyme activity (p = 0.34) or oxLDL/LDL (p = 0.32). Lp-PLA2 activity is an independent predictor of CHD risk and MS in a sample of subjects with diabetes mellitus. The association of Lp-PLA2 activity with oxLDL/LDL suggests that Lp-PLA2 may be a modulating factor in the process of atherosclerosis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Type:Article
Title:Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus
DOI:10.1016/j.atherosclerosis.2005.12.009
Keywords:Lp-PLA2, PAFAH, oxidised LDL, metabolic syndrome, diabetes, PLATELET-ACTIVATING-FACTOR, CORONARY-HEART-DISEASE, LOW-DENSITY-LIPOPROTEIN, C-REACTIVE PROTEIN, UKPDS RISK ENGINE, FACTOR-ACETYLHYDROLASE, PHOSPHOLIPASE A(2), PAF-ACETYLHYDROLASE, ARTERY-DISEASE, OXIDIZED LDL
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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