Hosseini-Khalili, AR; Thompson, J; Kehoe, A; Hopkinson, NS; Khoshbaten, A; Soroush, MR; ... Ghanei, M; + view all Hosseini-Khalili, AR; Thompson, J; Kehoe, A; Hopkinson, NS; Khoshbaten, A; Soroush, MR; Humphries, SE; Montgomery, H; Ghanei, M; - view fewer (2008) Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure. BMC Pulmonary Medicine , 8 , Article 15. 10.1186/1471-2466-8-15.
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Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear. The Renin Angiotensin System (RAS) has been implicated in lung inflammatory and fibrotic responses. Genetic variation within the gene coding for the Angiotensin Converting Enzyme (ACE), specifically the Insertion/Deletion polymorphism (I/D), is associated with variable levels of ACE and with the severity of several acute and chronic respiratory diseases. We hypothesized that the ACE genotype might influence the severity of late respiratory complications of mustard gas exposure.
|Title:||Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure|
|Open access status:||An open access version is available from UCL Discovery|
|Additional information:||© 2008 Hosseini-khalili et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC2527601|
|Keywords:||Adult, Chemical Warfare, Chemical Warfare Agents, Environmental Exposure, Female, Forced Expiratory Volume, Gene Deletion, Humans, Iran, Iraq, Lung Diseases, Male, Middle Aged, Mustard Gas, Polymorphism, Genetic, Renin, Spirometry|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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