Hosseini-Khalili, AR and Thompson, J and Kehoe, A and Hopkinson, NS and Khoshbaten, A and Soroush, MR and Humphries, SE and Montgomery, H and Ghanei, M (2008) Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure. BMC Pulm Med , 8 15 - ?. 10.1186/1471-2466-8-15.
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear. The Renin Angiotensin System (RAS) has been implicated in lung inflammatory and fibrotic responses. Genetic variation within the gene coding for the Angiotensin Converting Enzyme (ACE), specifically the Insertion/Deletion polymorphism (I/D), is associated with variable levels of ACE and with the severity of several acute and chronic respiratory diseases. We hypothesized that the ACE genotype might influence the severity of late respiratory complications of mustard gas exposure.
|Title:||Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure.|
|Open access status:||An open access publication|
|Additional information:||PMCID: PMC2527601|
|Keywords:||Adult, Chemical Warfare, Chemical Warfare Agents, Environmental Exposure, Female, Forced Expiratory Volume, Gene Deletion, Humans, Iran, Iraq, Lung Diseases, Male, Middle Aged, Mustard Gas, Polymorphism, Genetic, Renin, Spirometry|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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