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Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure

Hosseini-Khalili, AR; Thompson, J; Kehoe, A; Hopkinson, NS; Khoshbaten, A; Soroush, MR; ... Ghanei, M; + view all (2008) Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure. BMC Pulmonary Medicine , 8 , Article 15. 10.1186/1471-2466-8-15. Green and gold open access

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Abstract

Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear. The Renin Angiotensin System (RAS) has been implicated in lung inflammatory and fibrotic responses. Genetic variation within the gene coding for the Angiotensin Converting Enzyme (ACE), specifically the Insertion/Deletion polymorphism (I/D), is associated with variable levels of ACE and with the severity of several acute and chronic respiratory diseases. We hypothesized that the ACE genotype might influence the severity of late respiratory complications of mustard gas exposure.

Type:Article
Title:Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure
Location:England
Open access status:An open access publication. A version is also available from UCL Discovery.
DOI:10.1186/1471-2466-8-15
Publisher version:http://dx.doi.org/10.1186/1471-2466-8-15
Language:English
Additional information:© 2008 Hosseini-khalili et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC2527601
Keywords:Adult, Chemical Warfare, Chemical Warfare Agents, Environmental Exposure, Female, Forced Expiratory Volume, Gene Deletion, Humans, Iran, Iraq, Lung Diseases, Male, Middle Aged, Mustard Gas, Polymorphism, Genetic, Renin, Spirometry
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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