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Higher IL-6 levels but not IL6-174G > C or-572G > C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery

Sanders, J; Hawe, E; Brull, DJ; Hubbart, C; Lowe, GDO; Rumley, A; ... Montgomery, HE; + view all (2009) Higher IL-6 levels but not IL6-174G > C or-572G > C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery. ATHEROSCLEROSIS , 204 (1) 196 - 201. 10.1016/j.atherosclerosis.2008.08.032.

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Abstract

Large increases in inflammatory markers, particularly IL-6, occur after cardiac surgery. However, despite interventions to reduce the inflammatory response, great variability still remains which could in part be attributable to genetic predisposition. Since increased IL-6 levels following surgery are also associated with poorer Outcome we Sought to determine whether baseline and post-operative levels of Interleukin-6 (IL-6) and functional common variants of the Interleukin-6 (IL6) gene are associated with post-operative outcome following Coronary artery bypass grafting (CABG).Caucasian patients undergoing first-time elective CABG were studied. IL-6 levels were measured pre-, 6 h and 24 h following surgery and genotypes for IL6 gene variants -174G > C and -572G > C were obtained. Clinical data was collected daily until patient discharge. Patient outcome was categorised as with (ICUC, n = 177) and without (NICUC, n = 189) a post-operative complication during the ICU period and with (POC, n = 215) and without (NC, n = 151) a post-operative complication during hospitalisation. IL-6 levels pre- and at 24 h were greater in POC and ICUC than NC and NICUC, respectively. Pre- IL-6 levels independently predicted (for I standard deviation increase in log IL-6) POC (OR 1.4, 95% CI 1.1-1.7, p = 0.008) and ICUC (OR 1.3. 95% CI 1.0-1.6, p = 0.02) outcomes. Overall, the 11.6-572G > C had an effect over time on IL-6 levels (p = 0.04) and on IL-6 levels in NC (P = 0.008) and NICUC (p = 0.006). However, no associations were found with the IL6-572G > C or -174G > C variants on IL-6 levels at individual time-points or by outcome group. Thus, in conclusion, elevated pre-operative IL-6 levels, but not IL6 gene variants predict poor patient outcome following CABG. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Type:Article
Title:Higher IL-6 levels but not IL6-174G > C or-572G > C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery
DOI:10.1016/j.atherosclerosis.2008.08.032
Keywords:IL6-174G > C, IL-6-572G > C, Inflammation, Post-operative outcome, CABG, PLASMA INTERLEUKIN-6 CONCENTRATIONS, INFLAMMATORY RESPONSE SYNDROME, CONVERTING ENZYME-INHIBITION, CARDIOPULMONARY BYPASS, PROMOTER POLYMORPHISMS, CARDIAC-SURGERY, TNF-ALPHA, MYOCARDIAL-INFARCTION, SEPTIC SHOCK, DOUBLE-BLIND
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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