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Candidate gene association studies in abdominal aortic aneurysm disease: A review and meta-analysis

Thompson, AR; Drenos, F; Hafez, H; Humphries, SE; (2008) Candidate gene association studies in abdominal aortic aneurysm disease: A review and meta-analysis. EUR J VASC ENDOVASC , 35 (1) 19 - 30. 10.1016/j.ejvs.2007.07.022.

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Abstract

Background. Candidate gene analysis has been frequently used in attempts to understand the pathological processes involved in many aspects of AAA disease.Methods. This paper sets out a systems approach to reviewing AAA candidate gene analysis studies, whilst, explaining the key principles and design limitations of this universally applied technique. In addition we have performed a meta-analysis of six gene polymorphisms (ACE I/D, MTHFR + 677C > T, MMP9-1562C > T, Il-1Beta/3953C > T, eNOS 4a/4b & TIMP1/+434C > T) reported in multiple case control studies.Results and conclusions. Three of these polymorphisms were associated with a significant risk of AAA, ACE RR 1.33 [95% CI 1.20-1.48], MTHFR RR 1.14 [1.08-1.21] and MMP9 RR 1.09 [1.01-1.18]. These differences have been previously reported as equivocal, within a context of contradictory studies and as such this meta-analysis provides new evidence for their involvement in AAA disease. The plausibility of these findings is discussed within the context of a systems approach to the pathology of AAA disease. (C) 2007 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Type:Article
Title:Candidate gene association studies in abdominal aortic aneurysm disease: A review and meta-analysis
DOI:10.1016/j.ejvs.2007.07.022
Keywords:abdominal aortic aneurysm, candidate gene analysis, single neucleotide polymorphism, ANGIOTENSIN-CONVERTING-ENZYME, PLASMINOGEN-ACTIVATOR INHIBITOR-1, FACTOR ACETYLHYDROLASE GENE, RANDOMIZED CONTROLLED-TRIAL, RISK-FACTOR, NITRIC-OXIDE, CARDIOVASCULAR-DISEASE, MYOCARDIAL-INFARCTION, DELETION POLYMORPHISM, PREDISPOSING FACTOR
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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