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Left ventricular growth response to exercise and cigarette smoking: data from LARGE Heart

Payne, JR; Eleftheriou, KI; James, LE; Hawe, E; Mann, J; Stronge, A; ... Montgomery, HE; + view all (2006) Left ventricular growth response to exercise and cigarette smoking: data from LARGE Heart. HEART , 92 (12) 1784 - 1788. 10.1136/hrt.2006.088294.

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Abstract

Background: Increasing left ventricular mass is a risk factor for cardiovascular morbidity and mortality.Objective: To examine the possible association of smoking with the left ventricular growth response in men.Methods: Left ventricular mass was measured in 309 army recruits before and after an identical 12-week physical training programme. Left ventricular mass was determined using cardiovascular magnetic resonance.Results: Left ventricular mass increased with training (mean (standard deviation (SD)) 3.83 (10.81) g, p < 0.001). By univariate analysis, exercise-induced change in left ventricular mass was positively associated with cigarette smoking (mean (SD) 1.69 (11.10) g v 4.76 (10.23) g for non-smokers vex- and current smokers, respectively; p = 0.026), whereas age, height, diastolic and systolic blood pressure (SBP), alcohol consumption or indices of physical activity were not significantly associated with change in left ventricular mass. Multivariate analysis showed body weight, smoking status and SBP to be independent predictors of left ventricular mass (incremental R-2 = 3.4%, p = 0.004; R-2 = 4.9%, p = 0.024; and R-2 = 1.7%, p = 0.041, respectively).Conclusions: Cigarette smoking and SBP are associated with exercise-induced left ventricular growth in young men. The positive association of smoking with changes in left ventricular mass is surprising, given the limited exposure of these subjects to smoking, and although these data do not prove causation, they are of great interest to those trying to uncover the drivers of left ventricular hypertrophy, as well as to those examining the possible ill-effects of smoking in the young.

Type:Article
Title:Left ventricular growth response to exercise and cigarette smoking: data from LARGE Heart
DOI:10.1136/hrt.2006.088294
Keywords:CARDIOVASCULAR MAGNETIC-RESONANCE, BLOOD-PRESSURE, ESSENTIAL-HYPERTENSION, INSULIN-RESISTANCE, CARBON-MONOXIDE, HYPERTROPHY, MASS, DISEASE, PATHOPHYSIOLOGY, NICOTINE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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