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Gene-environment interaction in the determination of plasma levels of fibrinogen

Humphries, SE; Thomas, A; Montgomery, HE; Green, F; Winder, A; Miller, G; (1997) Gene-environment interaction in the determination of plasma levels of fibrinogen. In: FIBRINOLYSIS & PROTEOLYSIS. (pp. 3 - 7). CHURCHILL LIVINGSTONE

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Abstract

Functional sequence changes in the beta-gene promoter may have a direct effect on the rate of transcription and thus on plasma fibrinogen levels. A common G/A sequence variation has been detected at position -455 of the beta-fibrinogen promoter, with carriers of the A allele, representing roughly 20% of the population, consistently having higher fibrinogen levels than those with the genotype G/G (0.17 g/l higher, averaged over 8 published studies in Caucasian men). The magnitude of this genotype effect indicates that it is likely to be of biological significance in causing an elevated risk of thrombosis. However, the magnitude of this effect is modulated by several environmental factors and data will be presented to demonstrate interaction between genotype and age, smoking and physical exercise, in the determination of an individual's plasma fibrinogen levels.

Type:Proceedings paper
Title:Gene-environment interaction in the determination of plasma levels of fibrinogen
Event:3rd International Fibrinogen Symposium - Hemostasis, Inflammation and Cardiovascular Disease
Location:ULM, GERMANY
Dates:1996-05-03 - 1996-05-04
Keywords:MYOCARDIAL-INFARCTION, HEART-DISEASE, POLYMORPHISMS, RISK, VARIABILITY, VARIABLES, ADULTS, YOUNG, LOCI
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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