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Genetic determinants of arterial thrombosis

Grant, PJ; Humphries, SE; (1999) Genetic determinants of arterial thrombosis. BEST PRACT RES CL HA , 12 (3) 505 - 532.

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Abstract

This chapter describes examples of genetic variation involved in the function or regulation of a number of haemostatic proteins involved in the thrombotic process. In each case, the data suggest associations between genotype and disease and, particularly in the case of fibrinogen, PAI-I, Factor VII and Factor XIII, there is interaction between genotype and environment in determination of the relevant plasma level, providing a possible explanation for the differential response of individuals to their environment.

Type:Article
Title:Genetic determinants of arterial thrombosis
Keywords:polymorphisms, genes, coagulation, fibrinolysis, platelets, myocardial infarction, PLASMINOGEN-ACTIVATOR INHIBITOR-1, BETA-FIBRINOGEN GENE, ISCHEMIC-HEART-DISEASE, COAGULATION-FACTOR-XIII, ACUTE MYOCARDIAL-INFARCTION, PLATELET GLYCOPROTEIN IIIA, ACUTE-PHASE REACTION, FACTOR-VII GENE, A-SUBUNIT GENE, 4G/5G PROMOTER POLYMORPHISM
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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