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Are plasma triglycerides a good predictor of CHD risk?

Talmud, PJ; Hawe, E; Miller, GJ; Humphries, SE; (2004) Are plasma triglycerides a good predictor of CHD risk? International Congress Series , 1262 (C) pp. 207-210. 10.1016/S0531-5131(03)01733-3.

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We investigated which of the established lipid risk traits were the best risk predictors in a large prospective study. In multivariate analysis apoB and triglycerides (TG) gave the best risk prediction. Since very low density (VLDL) and low density lipoproteins (LDL) have one apoB molecule/particle, and VLDL is cleared faster than LDL, apoB levels reflect LDL number and TGs over 1.5 mmol/l are correlated with LDL size. From a genetic viewpoint we examined which of the genes in APOA5-A4-C3 cluster, using haplotype analysis, determined TG levels and coronary heart disease (CHD) risk. While APOA5 and APOC3 variants defined the major TG-raising haplotypes, APOA4 variants defined CHD risk haplotypes. Thus, TG per se is not the best risk predictor from both a phenotypic and genetic viewpoint. These data confirm the complex multifactorial nature of CHD risk. © 2003, Elsevier Science B.V. All rights reserved.

Type: Article
Title: Are plasma triglycerides a good predictor of CHD risk?
DOI: 10.1016/S0531-5131(03)01733-3
URI: http://discovery.ucl.ac.uk/id/eprint/97315
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