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Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease

Eriksson-Berg, M; Deguchi, H; Hawe, E; Scanavini, D; Orth-Gomer, K; Schenck-Gustafsson, K; ... Hamsten, A; + view all (2005) Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease. THROMB HAEMOSTASIS , 93 (2) 351 - 358. 10.1160/TH04-09-0616.

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Abstract

Plasma concentrations of coagulation factor VII (FVII) are determined by environmental and genetic factors. The influence of functional polymorphisms in the FVII gene (-670A>C, -402G>A, -401G>T and R353Q) and of established cardiovascular risk factors on plasma concentrations of FVII were investigated in a representative sample of middle-aged women with (n=238) and without (n=220) coronary heart disease (CHD). Specific and sensitive assays were used to measure FVII antigen (VIIag) and activated factor VII (VIIa). The effect of genotypes was markedly stronger on VIIa than on Wag, with the percentage variation in FVII levels accounted for by genotypes being greater in controls than in patients. Of the four polymorphisms examined, only the R353Q contributed to the variation in VIIa (24.1% in patients and 30.3% in controls). The -401G>T and -670A>C promoter polymorphisms together accounted for 12.2% of the variation in VIIag amongst patients whereas the -401G>T polymorphism alone contributed 19.7% of the variation in VIIag in controls. Serum triglycerides exerted a major influence on VIIag in both patients (13.0%) and controls (7.2%). Three main haplotypes emerged from the four polymorphisms which accounted for 98% of all haplotypes. Large-scale prospective studies of CHD including FVII haplotypes and sensitive and specific FVII measurements are needed in women.

Type:Article
Title:Influence of factor VII gene polymorphisms and environmental factors on plasma coagulation factor VII concentrations in middle-aged women with and without manifest coronary heart disease
DOI:10.1160/TH04-09-0616
Keywords:coagulation, factor VII, myocardial infarction, genetics, ACTIVATED FACTOR-VII, RISK-FACTORS, HEMOSTATIC FACTORS, CARDIOVASCULAR-DISEASES, HEALTHY-MEN, IN-VITRO, POPULATION, TRIGLYCERIDES, FIBRINOGEN, GENDER
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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