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The angiotensin-converting enzyme gene and the angiotensin II type I receptor gene as candidate genes for microalbuminuria - A study in nondiabetic and non-insulin-dependent diabetic subjects.
ARTERIOSCL THROM VAS
2188 - 2191.
Familial clustering of microalbuminuria with cardiovascular disease suggests a possible common genetic antecedent. We have tested the hypothesis that the angiotensin-converting enzyme (ACE) DD genotype and the angiotensin II type I receptor (AT(1)R) gene C allele represent the common link between microalbuminuria and coronary heart disease. The frequency of polymorphisms of the ACE and AT(1)R genes were investigated in 509 nondiabetic white subjects and in 86 noninsulin-dependent diabetic white patients. There was no significant difference in albumin excretion rate between the genotypes in nondiabetic subjects on either a daytime or an overnight sample or in diabetic subjects expressed as a normalized albumin concentration on an untimed morning urine collection. We have found no evidence for an association between polymorphism of the ACE or AT(1)R genes and microalbuminuria in two groups of subjects without insulin-dependent diabetes.
|Title:||The angiotensin-converting enzyme gene and the angiotensin II type I receptor gene as candidate genes for microalbuminuria - A study in nondiabetic and non-insulin-dependent diabetic subjects|
|Keywords:||cardiovascular disease, microalbuminuria, non-insulin-dependent diabetes, angiotensin-converting enzyme gene, angiotensin II type I receptor gene, INSERTION DELETION POLYMORPHISM, CORONARY HEART-DISEASE, MYOCARDIAL-INFARCTION, VASCULAR-DISEASE, ACE GENE, NEPHROPATHY, ASSOCIATIONS, MELLITUS, RISK, RETINOPATHY|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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