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W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample

O'Dell, SD; Bolla, MK; Miller, GJ; Cooper, JA; Humphries, SE; Day, INM; (1998) W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample. INT J OBESITY , 22 (4) 377 - 379.

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Abstract

We have investigated the W64R (Trp64Arg) mutation in the beta-3-adrenergic receptor in 2270 healthy British males aged 50-61 y. The frequency of the rare R allele was 0.07 (95% confidence interval (CI) 0.06-0.08). The men showed an absence of association between W64R genotype and weight or height, both in the whole sample and in each quintile of the body mass index (BMI), and there was no association with tendency to gain weight. The W64R heterozygous state appears not to be a major contributing factor to obesity in the general population.

Type:Article
Title:W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample
Keywords:body-weight, BMI, beta-3-adrenergic receptor gene, W64R mutation, DIAGONAL GEL-ELECTROPHORESIS, BETA(3)-ADRENERGIC RECEPTOR, INSULIN-RESISTANCE, TRP64ARG MUTATION, OBESITY, POLYMORPHISM, ASSOCIATION, GAIN, FAT
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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