Jones, KG and Brull, DJ and Brown, LC and Sian, M and Greenhalgh, RM and Humphries, SE and Powell, JT (2001) Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation , 103 (18) 2260 - 2265.
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Abstract
BACKGROUND: Abdominal aortic aneurysm is a multifactorial disorder in which inflammation is an important pathophysiological feature. In explant culture, aneurysm biopsies secrete large amounts of interleukin- 6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased. METHODS AND RESULTS: We investigated, in 19 patients, whether aneurysm wall was an important source of circulating IL-6. We also tested the hypotheses, in 466 patients with a small aneurysm, that (1) high concentrations of circulating IL-6 signaled rapid aneurysm growth and (2) the -174 G-->C polymorphism in the IL-6 promoter predicted survival. For 19 patients with large or inflammatory aneurysms, the concentration of IL-6 was higher in the iliac arteries than the brachial arteries (median difference 26.5 pg/mL, this difference increasing with aneurysm diameter, P=0.01). In 466 patients with small aneurysms, the frequency of the -174 C allele (0.40) was similar to that in a normal healthy population. Patients of GG genotype had lower plasma concentrations of IL-6 than patients of GC and CC genotypes (medians 1.9, 4.8, and 15.6 pg/mL, respectively, Kruskal-Wallis P=0.047). Cardiovascular and all-cause mortalities were lower for patients of GG genotype than for patients of GC and CC genotype: hazard ratios 0.32 (95% CI 0.12 to 0.93), P=0.036, and 0.51 (95% CI 0.25 to 1.00), P=0.05, respectively. There was no association between plasma IL-6 or IL-6 genotype and aneurysm growth. CONCLUSIONS: Aortic aneurysms appear to be an important source of circulating IL-6, the concentration being influenced by genotype. For patients with small aneurysms, the -174 G-->C IL-6 genotype predicts future cardiovascular mortality
| Type: | Article |
|---|---|
| Title: | Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms |
| Additional information: | UI - 21266742 LA - eng RN - 0 (Interleukin-6) RN - 9001-32-5 (Fibrinogen) RN - 9007-41-4 (C-Reactive Protein) PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial DA - 20010524 IS - 1524-4539 SB - AIM SB - IM CY - United States |
| Keywords: | abdominal, abdominal aortic aneurysm, Aged, ALL-CAUSE MORTALITY, Allele, Alleles, Aneurysm, ANEURYSMS, Aortic Aneurysm, Aortic Aneurysm, Abdominal, Arteries, artery, Association, Biopsy, Blood, Blood Pressure, Brachial Artery, C REACTIVE PROTEIN, C-Reactive Protein, C-REACTIVE-PROTEIN, cardiovascular, CARDIOVASCULAR MORTALITY, CC, circulating, clinical, Clinical trial, CLINICAL-TRIAL, Concentration, CONTROLLED TRIAL, culture, diagnosis, Diameter, difference, Disease Progression, DISORDER, Electrocardiography, Explant Culture, Female, Fibrinogen, Follow-Up Studies, FREQUENCIES, FREQUENCY, future, genetics, Genotype, genotypes, growth, Hazard, HEALTHY, High concentration, IL-6, Iliac Artery, IM, Inflammation, Interleukin 6, Interleukin-6, LA, Male, metabolism, Methods, Middle Age, MORTALITY, Patient, patients, plasma, PLASMA-CONCENTRATION, PLASMA-CONCENTRATIONS, Polymorphism, Polymorphism (Genetics), population, Predictive Value of Tests, Prognosis, PROMOTER, Promoter Regions (Genetics), PROTEIN, randomized, RANDOMIZED CONTROLLED TRIAL, RATIO, Result, small, STATE, STATES, Support, Non-U.S.Gov't, surgery, SURVIVAL, Survival Rate, Tomography, X-Ray Computed, TRIAL, united, United States, UNITED-STATES, vascular, Vascular Surgery, WALL |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
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