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Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study

Hubacek, JA; Pitha, J; Skodova, Z; Poledne, R; Lanska, V; Waterworth, DM; ... Talmud, PJ; + view all (2003) Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study. CLIN BIOCHEM , 36 (4) 263 - 267. 10.1016/S0009-9120(03)00025-0.

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Abstract

Objectives: To evaluate the influence of variation in the genes for apolipoprotein E (APOE; epsilon2, epsilon3, epsilon4) and cholesterol-7alpha hydroxylase (CYP-7A1; -204A-->C) on plasma lipid level changes.Design and methods: 131 males for whom dietary composition markedly changed and total cholesterol decreased (from 6.21 +/- 1.31 mmol/L in 1988 - 5.43 +/- 1.06 mmol/L in 1996). over an 8 yr follow-up study. Polymorphisms were investigated using PCR.Results: APOE genotype influenced plasma total and LDL cholesterol, with carriers of the epsilon4 having the highest and epsilon2 carriers the lowest levels, this reached borderline significance for cholesterol in 1988 (p = 0.06) and strongly affected the 1996 levels of LDL cholesterol (p = 0.008). However, APOE did not influence the change in these measures over time. In contrast, the CYP-7A1 -204A-->C polymorphism did not affect lipid measures per se but was strongly associated with a dec tease in plasma total cholesterol [AA -0.38 (+/- 0.20) mmol/L, AC -0.65 +/- (0.08), CC -1.33 (+/- 0.3) mmol/L, p = 0.01] over the 8 yr time period.Conclusions: Variation in the CYP-7A1 gene may play an important role in an individual's sensitivity to dietary composition. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.

Type:Article
Title:Polymorphisms in CYP-7A1, not APOE, influence the change in plasma lipids in response to population dietary change in an 8 year follow-up; results from the Czech MONICA study
DOI:10.1016/S0009-9120(03)00025-0
Keywords:cholesterol 7-alpha hydroxylase, apolipoprotein E, lipids, polymorphism, diet, APOLIPOPROTEIN-E POLYMORPHISM, DENSITY-LIPOPROTEIN CHOLESTEROL, GENE, 7-ALPHA-HYDROXYLASE, EXPRESSION, METABOLISM, DISEASE, RISK
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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