Austin, MA; Edwards, KL; McNeely, MJ; Chandler, WL; Leonetti, DL; Talmud, PJ; ... Fujimoto, WY; + view all Austin, MA; Edwards, KL; McNeely, MJ; Chandler, WL; Leonetti, DL; Talmud, PJ; Humphries, SE; Fujimoto, WY; - view fewer (2004) Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese Americans. DIABETES , 53 (4) 1166 - 1169.
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A rapidly growing body of evidence demonstrates important associations between the metabolic syndrome, characterized by a cluster of risk factors or phenotypes that include dyslipidemia, central obesity, hypertension, and hyperinsidinemia, and both cardiovascular disease and type 2 diabetes. The purpose of the present study was to characterize the metabolic syndrome in a sample of 432 individuals from 68 Japanese-American families, using factor analysis of quantitative phenotypes, and to estimate the heritability of these independent factors. Using nine characteristic phenotypes that included LDL particle size and C-reactive protein (CRP), factor analysis identified three multivariate factors interpreted as lipids, body fat/insulin/glucose/CRP, and blood pressure, explaining 65% of the variance. Heritability analysis revealed significant genetic effects on all of the factors: lipids (h(2) = 0.52, P < 0.001), body fat/insulin/glucose/CRP (h(2) = 0.27, P = 0.016), and blood pressure (h(2) = 0.25, P = 0.026). This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome.
|Title:||Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese Americans|
|Keywords:||INSULIN-RESISTANCE SYNDROME, CORONARY-HEART-DISEASE, MIDDLE-AGED MEN, SYNDROME PREDICTS, DIABETES-MELLITUS, ELDERLY MEN, WOMEN, RISK, COMPONENTS, EVENTS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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