UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.

Humphries, S; Bauters, C; Meirhaeghe, A; Luong, L; Bertrand, M; Amouyel, P; (2002) The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis. Eur Heart J , 23 (9) pp. 721-725. 10.1053/euhj.2001.2895.

Full text not available from this repository.

Abstract

AIMS: Intracoronary ultrasound studies in humans show that chronic remodelling rather than neointimal hyperplasia is the mechanism of restenosis. Stent implantation limits this remodelling process and significantly reduces restenosis. MMP3 (Stromelysin-1), a member of the matrix metalloproteinase family may play a role in this remodelling. We used a functional polymorphism (with alleles designated 5A or 6A) in the promoter of the MMP3 gene to examine the possible role of MMP3 in restenosis. METHODS AND RESULTS: Genotypes were determined in a series of consecutive patients who underwent conventional balloon coronary angioplasty without stenting (n=287) or who also had successful implantation of a Palmaz-Schatz stent (stent) (n=198). For all patients restenosis was estimated at 6 months using quantitative computer-assisted angiography. The minimal luminal diameters before and after the procedures did not differ significantly between genotypes. At follow-up in the patients without stent, those with the 6A6A genotype had an increased degree of restenosis after coronary angioplasty compared to those with one or more 5A alleles, with a greater diameter stenosis (52+/-21% vs 45+/-19%, P=0.012), and a greater late loss (0.58+/-0.59 mm vs 0.38+/-0.59 mm, P=0.038). By contrast, in the stented patients MMP3 genotype was not associated with any angiographically determined measure of vessel dimensions. CONCLUSIONS: These data imply the involvement of MMP3 in chronic remodelling after conventional balloon angioplasty, and suggest that the 6A6A MMP3 genotype is a genetic susceptibility factor for restenosis after angioplasty without stenting.

Type: Article
Title: The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.
Location: England
DOI: 10.1053/euhj.2001.2895
Keywords: Aged, Alleles, Angioplasty, Balloon, Coronary, Blood Vessel Prosthesis Implantation, Coronary Restenosis, Coronary Stenosis, Female, Follow-Up Studies, France, Genotype, Humans, Male, Matrix Metalloproteinase 3, Middle Aged, Polymorphism, Genetic, Promoter Regions, Genetic, Risk Factors, Stents
URI: http://discovery.ucl.ac.uk/id/eprint/97168
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item