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Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population

Chapman, CML; Beilby, JP; Humphries, SE; Palmer, LJ; Thompson, PL; Hung, J; (2003) Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population. EUR HEART J , 24 (16) 1494 - 1499. 10.1016/S0195-668X(03)00313-0.

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Abstract

Aims Atherosclerosis can be viewed as a low grade inflammatory process, and genetic polymorphisms within cytokines are candidate risk factors for the development of atherosclerosis. We examined the association of a common functional variant in the IL-6 gene with carotid intimal-medial wall thickness (IMT) and the presence of plaques in a randomly selected, cross-sectional Australian population.Methods B-mode carotid ultrasound was performed on 1109 subjects aged 27-77 years, who were genotyped for the IL-6 polymorphism (-174G>C) and assessed for conventional Cardiovascular risk factors.Results The frequency of the IL-6 -174C allele was 0.41. Initial univariate analysis showed no association of the IL-6 -174G>C polymorphism with carotid IMT. Multivariate analysis however showed an association of the IL-6 -174C allele with increased IMT in subjects older than the median age of 53 years (P=0.005). Initial univariate analysis of the IL-6 -174 G>C polymorphism and carotid plaque showed no association in the whole sample. In multivariate analysis the - 174C allele was independently associated with an increased risk of carotid plaque in the whole sample (CC vs GG, OR=2.22, 95% CI=1.32 to 3.73, P=0.003).Conclusions This study shows that the IL-6 -174G>C variant is independently associated with carotid plaque formation in the whole population and an increased carotid IMT in older subjects within a randomly selected, cross-sectional Australian population. (C) 2003 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.

Type:Article
Title:Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population
DOI:10.1016/S0195-668X(03)00313-0
Keywords:interleukin-6, polymorphism, intimal-medial thickness, carotid ultrasound, carotid atherosclerosis, INTIMA-MEDIA THICKNESS, CORONARY-HEART-DISEASE, MYOCARDIAL-INFARCTION, PROMOTER POLYMORPHISM, CARDIOVASCULAR-DISEASE, G/C POLYMORPHISM, ARTERY INTIMA, GENE PROMOTER, PLASMA-LEVELS, HEALTHY-MEN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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