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Topics in prion cell biology

Brockes, JP; (1999) Topics in prion cell biology. CURR OPIN NEUROBIOL , 9 (5) 571 - 577.

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Abstract

Recent studies of a transmembrane form of the prion protein (PrP) have indicated its importance for neuropathogenesis in certain contexts, and have analysed the transacting factors at the endoplasmic reticulum and the mutations within PrP that regulate its appearance. A significant focus for our understanding of the normal role of PrP has emerged from its interaction with copper ions. Studies on two yeast prions have analysed the structure and phenotype of the aggregated conformers underlying the prion state, as well as the interactions regulating their formation and turnover within a dividing cell.

Type: Article
Title: Topics in prion cell biology
Keywords: CLATHRIN-COATED PITS, PROTEIN EXPRESSION, YEAST PRION, ENDOPLASMIC-RETICULUM, MONOCLONAL-ANTIBODY, RELEASE FACTORS, COPPER-BINDING, N-TERMINUS, PROPAGATION, MICE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/97117
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