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Optimal timing for collection of PBPC after glycosylated G-CSF administration

Watts, MJ; Addison, I; Ings, SJ; Long, SG; Hartley, S; Warrington, S; Boyce, M; (1998) Optimal timing for collection of PBPC after glycosylated G-CSF administration. BONE MARROW TRANSPL , 21 (4) 365 - 368.

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Abstract

Daily administration of granulocyte colony-stimulating Factor (G-CSF) results in progenitor cell mobilization with maximum blood levels achieved after 4-7 days, In this study the short-term effects of glycosylated G-CSF at a dose of 5 mu g/kg s.c. were determined so as to allow optimization of the timing of progenitor cell collection, In the first study involving 20 normal volunteers, a significant fall in neutrophil count and G-CSF levels was observed 2 h after the G-CSF injection, To investigate this phenomenon serial measurements were made in a further six volunteers after the 6th daily injection of G-CSF, A fall in the neutrophil count occurred which was maximal at 1 h and recovered to baseline within 3 h, There was also a fall in CD34(+) cells (P = 0.034), GM-CFC (P = 0.025) and BFU-E (P = 0.066) and recovery to baseline levels took 4-12 h, We conclude that glycosylated G-CSF should not be given immediately prior to stem cell collection.

Type: Article
Title: Optimal timing for collection of PBPC after glycosylated G-CSF administration
Keywords: progenitor cells, G-CSF, mobilization, kinetics, apheresis timing, COLONY-STIMULATING FACTOR, BLOOD STEM-CELLS, PERIPHERAL-BLOOD, PROGENITOR CELLS, MOBILIZATION, TRANSPLANTATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/97017
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