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The noradrenergic system influences the fate of Cajal-Retzius cells in the developing cerebral cortex

Naqui, SZH; Harris, BS; Thomaidou, D; Parnavelas, JG; (1999) The noradrenergic system influences the fate of Cajal-Retzius cells in the developing cerebral cortex. DEV BRAIN RES , 113 (1-2) 75 - 82.

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Abstract

Cajal-Retzius cells are neurons prominently located in layer I of the developing cerebral cortex. They are the first neurons to be born in the cortex reaching maturity long before any other cortical neuronal cell type; later in development they degenerate and/or change phenotype. The noradrenergic system, which originates in the locus coeruleus in the brain stem, is one of the earliest axonal systems to enter the cortex forming contacts with Cajal-Retzius cells in layer I. Here we followed the course of development of the Cajal-Retzius cells in postnatal life in animals depleted of noradrenaline in the cortex. We found that removal of this system after birth resulted in significantly more Cajal-Retzius cells during the first 2 weeks of life. This may be due to the observed decline in the number of dying cells in layer I of these animals during the same period. We speculate that the noradrenergic system regulates the development of Cajal-Retzius cells which have been implicated in neuronal migration and laminar formation in the cerebral cortex. (C) 1999 Elsevier Science B.V. All rights reserved.

Type: Article
Title: The noradrenergic system influences the fate of Cajal-Retzius cells in the developing cerebral cortex
Keywords: Cajal-Retzius cell, noradrenaline, neocortex, development, electron microscopy, apoptosis, NEONATAL 6-HYDROXYDOPAMINE TREATMENT, VISUAL CORTICAL PLASTICITY, MONOAMINE NEURONS, RAT, ONTOGENY, MOUSE, NORADRENALINE, INNERVATION, NEOCORTEX, ORGANIZATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/96511
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