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SUCCESS OF KIDNEY-TRANSPLANTATION IN OXALOSIS IS UNRELATED TO RESIDUAL HEPATIC ENZYME-ACTIVITY

KATZ, A; FREESE, D; DANPURE, CJ; SCHEINMAN, JI; MAUER, SM; (1992) SUCCESS OF KIDNEY-TRANSPLANTATION IN OXALOSIS IS UNRELATED TO RESIDUAL HEPATIC ENZYME-ACTIVITY. KIDNEY INT , 42 (6) 1408 - 1411.

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Abstract

We evaluated hepatic alanine glyoxylate aminotransferase (AGT) activity in percutaneous hepatic biopsy material obtained from four children with long-term renal allograft function following transplantation for primary hyperoxaluria type 1 (PH 1). The study was performed to determine whether these successes had occurred because relatively high residual levels of AGT activity had introduced a selection bias. The children ranged from seven months to eight years at transplant and are currently well 7 to 11 years later, with no oxalate deposition on repeated allograft biopsies and creatinine clearances of 80 to 128 ml/min/1.73 m2. AGT activity ranged from 0 to 13.8%, and in two of three patients with detectable levels the AGT was in mitochondria rather than peroxisomes. These results indicate that long-term renal allograft success can occur in spite of severe AGT deficiency. Thus, the therapeutic choice of kidney alone versus combined kidney-liver transplant cannot currently be made by measuring residual hepatic AGT in PH 1. Kidney transplant alone remains a reasonable initial therapeutic alternative for patients with recent onset of renal insufficiency due to PH 1.

Type: Article
Title: SUCCESS OF KIDNEY-TRANSPLANTATION IN OXALOSIS IS UNRELATED TO RESIDUAL HEPATIC ENZYME-ACTIVITY
Keywords: PRIMARY HYPEROXALURIA TYPE-1, COMBINED LIVER-KIDNEY, GLYOXYLATE AMINOTRANSFERASE, RENAL-TRANSPLANTATION, OXALATE DYNAMICS, ALANINE, FAILURE, IDENTIFICATION, HEMODIALYSIS, STRATEGIES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/96198
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