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Use of a strategy based on calculated risk scores in managing cardiovascular risk factors in a large British cohort of patients with systemic lupus erythematosus

O'Neill, SG; Pego-Reigosa, JM; Hingorani, AD; Bessant, R; Isenberg, DA; Rahman, A; (2009) Use of a strategy based on calculated risk scores in managing cardiovascular risk factors in a large British cohort of patients with systemic lupus erythematosus. RHEUMATOLOGY , 48 (5) 573 - 575. 10.1093/rheumatology/kep037.

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Abstract

Objective. To develop a strategy for stratifying risk of cardiovascular disease (CVD) in a cohort of patients with SLE and to test the usefulness of this strategy in rationalizing management of cardiovascular risk factors.Methods. For each patient, data were collected once each year to allow calculation of risk of developing CVD in the next 10 years. Those with risk values 7.5 were considered for intervention to reduce risk. The risk figures and effect of this strategy on management of the cohort as a whole were assessed after 3 years. Patients who had been identified as smokers in 2005 were contacted in 2008 to assess changes in their smoking behaviour.Results. Over 3 years, 308 patients (90) of the cohort had CVD risk assessed at least once. Although 10-year CVD risk exceeded 7.5 in 35 patients, the majority (24) of these had either diabetes mellitus or previous CVD for which established cardiovascular risk reduction protocols already exist. Calculation of risk scores did not alter management in 96.5 of the patients. Ninety percent of the smokers remembered being counselled about smoking in the lupus clinic, 70 had received help to reduce smoking and 47 had either reduced or stopped.Conclusion. A protocol mandating regular assessment of cardiovascular risk factors in our lupus clinic resulted in this issue being discussed with 90 of the patients and there was some evidence of an impact on smoking. However, use of these factors to calculate 10-year risk scores did not alter management in over 96 of the cases.

Type: Article
Title: Use of a strategy based on calculated risk scores in managing cardiovascular risk factors in a large British cohort of patients with systemic lupus erythematosus
DOI: 10.1093/rheumatology/kep037
Keywords: Systemic lupus erythematosus, Cardiovascular disease, Smoking, Risk assessment, CORONARY-HEART-DISEASE, ACCELERATED ATHEROSCLEROSIS, GUIDELINES, MANAGEMENT, PROGRAM, TRIALS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/96105
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