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Differences in activities of the enzymes of nucleotide metabolism and its implications for cardiac xenotransplantation.

Yuen, AHY; Khalpey, Z; Lavitrano, M; McGregor, CGA; Kalsi, KK; Yacoub, MH; Smolenski, RT; (2006) Differences in activities of the enzymes of nucleotide metabolism and its implications for cardiac xenotransplantation. Nucleosides Nucleotides Nucleic Acids , 25 (9-11) pp. 1221-1224. 10.1080/15257770600894204.

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Abstract

Xenotransplantation is one be possible solution for a severe shortage of human organs available for transplantation. However, only a few studies addressed metabolic compatibility of transplanted animal organs. Our aim was to compare activities of adenosine metabolizing enzymes in the heart of different species that are relevant to clinical or experimental xenotransplantation. We noted fundamental differences: ecto-5' nucleotidease (E5' N) activity was 4-fold lower in pig and baboon hearts compared to the human hearts while mouse activity was compatible with human and rat activity was three times higher than human. There also were significant differences in AMP-deaminase (AMPD), adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) activities. We conclude that differences in nucleotide metabolism may contribute to organ dysfunction after xenotransplantation.

Type: Article
Title: Differences in activities of the enzymes of nucleotide metabolism and its implications for cardiac xenotransplantation.
Location: United States
DOI: 10.1080/15257770600894204
Keywords: 5'-Nucleotidase, AMP Deaminase, Adenosine, Adenosine Deaminase, Animals, Heart Transplantation, Humans, Mice, Nucleotides, Papio, Purine-Nucleoside Phosphorylase, Rats, Species Specificity, Swine, Transplantation, Heterologous
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: http://discovery.ucl.ac.uk/id/eprint/95904
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