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Enriching the environment of alpha CaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP

Parsley, SL; Pilgram, SM; Soto, F; Giese, KP; Edwards, FA; (2007) Enriching the environment of alpha CaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP. LEARN MEMORY , 14 (1-2) 75 - 83. 10.1101/lm.356607. Gold open access

Abstract

alpha CaMKIIT286A mutant mice lack long-term potentiation (LTP) in the hippocampal CA1 region and are impaired in spatial learning. In situ hybridization confirms that the mutant mice show the same developmental expression of alpha CaMKII as their wild-type littermates. A simple hypothesis would suggest that if LTP is a substrate for learning, then enriching the environment should cause learning-dependent changes in wild-type mice that have LTP. Such changes would not be seen in LTP-deficient alpha CaMKIIT286A mutants. Excitatory synaptic currents in CA1 neurons, recorded with patch clamp in brain slices, revealed that enrichment induces an increase in glutamate release probability and a decreased miniature current amplitude. Confocal microscopy also showed dendritic spine density to be reduced. However, contrary to the hypothesis above, these enrichment-induced changes occur only in the mutant mice and are not detectable in wild-type littermates. We suggest that enrichment induces alpha CaMKII-independent changes in both wild-type and mutant mice. Such changes may be subsequently reversed in wild-type animals via alpha CaMKII-dependent mechanisms, such as LTP. Reversal of plasticity has long been hypothesized to be essential for the hippocampus to maintain its role in memory processing. The inability to reverse plasticity in alpha CaMKIIT286A mutant mice would then result in impairment of spatial learning.

Type: Article
Title: Enriching the environment of alpha CaMKIIT286A mutant mice reveals that LTD occurs in memory processing but must be subsequently reversed by LTP
Open access status: An open access publication
DOI: 10.1101/lm.356607
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC18385...
Keywords: LONG-TERM POTENTIATION, DEPENDENT PROTEIN-KINASE, DEVELOPING NERVOUS-SYSTEM, SYNAPTIC PLASTICITY, RAT HIPPOCAMPUS, NOVELTY ACQUISITION, SILENT SYNAPSES, COMPLEXIN II, CA1 REGION, CAMKII
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/9563
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