Luthert, PJ; Chong, NHV; (1998) Photoreceptor rescue. EYE , 12 591 - 596.
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Photoreceptor cell death is the final, irreversible event in many blinding diseases including retinitis pigmentosa, age-related macular disease and retinal detachment. This paper examines the potential strategies for preventing photoreceptor cell death in the context of current understanding of the mechanisms of cell death. There is evidence to suggest that photoreceptor cells are inherently vulnerable, apoptosis is the final common pathway of photoreceptor cell loss, and other retinal cells play an important role in the survival of rods and cones. Furthermore, the rationale of using neurotrophic factors as therapeutic agents in retinal degeneration is discussed in detail. Photoreceptor rescue by manipulation of genes involved in apoptosis and some pharmacological agents is also described.
|Keywords:||apoptosis, gene manipulation, neurotrophic factors, photoreceptor, retinal degeneration, retinitis pigmentosa, FIBROBLAST GROWTH-FACTOR, CILIARY NEUROTROPHIC FACTOR, INHERITED RETINAL DYSTROPHY, PROGRAMMED CELL-DEATH, MESSENGER-RNAS, CONSTANT LIGHT, GANGLION-CELLS, RCS RATS, DEGENERATION, CNTF|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology|
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