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Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media

Wilden, JD and Judd, DB and Caddick, S (2005) Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media. TETRAHEDRON LETT , 46 (44) 7637 - 7640. 10.1016/j.tetlet.2005.08.088.

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Abstract

We report here, a method of accelerating the rate of aminolysis of PFP sulfonates to yield sulfonamides using tetrabutylammonium salts. We have previously explored the utility of employing PFP sulfonates in the formation of sulfonamides; however we demonstrate here the advantages of combining the existing methodology with a revised protocol which allows the diversity within both the sulfonate ester and the amine to be extended. (c) 2005 Elsevier Ltd. All rights reserved.

Type:Article
Title:Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media
DOI:10.1016/j.tetlet.2005.08.088
Keywords:pentafluorophenyl sulfonates, aminolysis, rate enhancement, sulfonamides
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
UCL > VP Enterprise

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