Banaji, M.;
Tachtsidis, I.;
Delpy, D.;
Baigent, S.;
(2005)
A physiological model of cerebral blood flow control.
Mathematical Biosciences
, 194
(2)
pp. 125-173.
10.1016/j.mbs.2004.10.005.
Abstract
The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results.
| Type: | Article |
|---|---|
| Title: | A physiological model of cerebral blood flow control |
| DOI: | 10.1016/j.mbs.2004.10.005 |
| Publisher version: | http://dx.doi.org/10.1016/j.mbs.2004.10.005 |
| Language: | English |
| Keywords: | Human brain circulation, mathematical model, autoregulation |
| UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering |
| URI: | http://discovery.ucl.ac.uk/id/eprint/9444 |
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