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A physiological model of cerebral blood flow control

Banaji, M.; Tachtsidis, I.; Delpy, D.; Baigent, S.; (2005) A physiological model of cerebral blood flow control. Mathematical Biosciences , 194 (2) pp. 125-173. 10.1016/j.mbs.2004.10.005.

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The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results.

Title:A physiological model of cerebral blood flow control
Publisher version:http://dx.doi.org/10.1016/j.mbs.2004.10.005
Keywords:Human brain circulation, mathematical model, autoregulation
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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