A physiological model of cerebral blood flow control.
The construction of a computational model of the human brain circulation is described. We combine an existing model of the biophysics of the circulatory system, a basic model of brain metabolic biochemistry, and a model of the functioning of vascular smooth muscle (VSM) into a single model. This represents a first attempt to understand how the numerous different feedback pathways by which cerebral blood flow is controlled interact with each other. The present work comprises the following: Descriptions of the physiology underlying the model; general comments on the processes by which this physiology is translated into mathematics; comments on parameter setting; and some simulation results. The simulations presented are preliminary, but show qualitative agreement between model behaviour and experimental results.
|Title:||A physiological model of cerebral blood flow control|
|Keywords:||Human brain circulation, mathematical model, autoregulation|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering|
Archive Staff Only