Boudjemline, Y and Schievano, S and Bonnet, C and Coats, L and Agnoletti, G and Khambadkone, S and Bonnet, D and Deanfield, J and Sidi, D and Bonhoeffer, P (2005) Off-pump replacement of the pulmonary valve in large right ventricular outflow tracts: A hybrid approach. J THORAC CARDIOV SUR , 129 (4) 831 - 837. 10.1016/j.jtcvs.2004.10.027.
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Background: Percutaneous pulmonary valve replacement has recently been introduced and is under investigation in humans. This technique is, however, limited to patients with a right ventricular outflow tract that does not exceed 22 mm in diameter. We report our experience of off-pump pulmonary valve replacement using a hybrid approach in animals with large right ventricular outflow tracts.Methods: Eight ewes were included in the protocol and were equally divided into 2 groups. A left thoracotomy was first performed, and the main pulmonary artery was banded by using 2 radiopaque rings with a diameter of 18 mm that allowed for further pulmonary valve replacement. We then intended to implant a valved stent either percutaneously (group 1) or through a transventricular approach (group 2). All animals were killed after valve implantation. The operation allowed the pulmonary diameter to be reduced from 30 to 17.6 mm.Results: The right ventricular pressure did not significantly increase after reduction of the pulmonary artery diameter (25 vs 36 mm Hg). Subsequent pulmonary valve replacement through a percutaneous or a transventricular approach was always possible without any requirement for extracorporeal circulation. All devices were successfully delivered inside the pulmonary artery banding and were functioning perfectly at early evaluation.Conclusions: Implantation of a pulmonary valve is possible in ewes through a hybrid approach when the right ventricular outflow tract exceeds 22 mm in diameter. This involves both surgeons and interventionists and allows for a staged procedure in which the valvulation is performed percutaneously or, for a combined hybrid approach, in which the valve is implanted off pump transventricularly during the same operation.
|Title:||Off-pump replacement of the pulmonary valve in large right ventricular outflow tracts: A hybrid approach|
|Keywords:||TRANSCATHETER IMPLANTATION, TETRALOGY, FALLOT, DYSFUNCTION, REPAIR|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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