Zhong, S and Salomoni, P and Pandolfi, PP (2000) The transcriptional role of PML and the nuclear body. NAT CELL BIOL , 2 (5) E85 - E90.
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The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear domain, the nuclear body. Various functions have been attributed to the PML nuclear body, but its main biochemical role is still unclear. Recent findings indicate that PML is essential for the proper formation of the nuclear body and can act as a transcriptional cofactor. Here we summarize the current understanding of the biological functions of PML and the nuclear body, and discuss a role for these intra-nuclear structures in the regulation of transcription.
|Title:||The transcriptional role of PML and the nuclear body|
|Keywords:||ACUTE PROMYELOCYTIC LEUKEMIA, CREB-BINDING-PROTEIN, UBIQUITIN-SPECIFIC PROTEASE, RING FINGER DOMAIN, RAR-ALPHA, GROWTH-SUPPRESSOR, TRANSACTIVATION PROPERTIES, HUMAN CYTOMEGALOVIRUS, SUMO-1 MODIFICATION, GENE-EXPRESSION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology|
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