An enantioselective synthesis of the bicyclic core of the marine natural product awajanomycin.
1819 - 1821.
A concise stereoselective synthesis of the N-benzylated bicyclic core of the marine natural product awajanomycin is described starting with naturally Occurring L-alanine. Key steps in the synthesis include a ring-closing metathesis to establish a delta-lactam ring followed by a stereoselective hydroxylation to instal the quaternary centre. (C) 2010 Elsevier Ltd. All rights reserved.
|Title:||An enantioselective synthesis of the bicyclic core of the marine natural product awajanomycin|
|Keywords:||Ring-closing metathesis, delta-Lactam, Acremonium sp., Diastereoselective hydroxylation, VINYL HALIDES, LACTONES, CARBONYLATION, DERIVATIVES, METATHESIS, ALCOHOLS, ROUTE|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
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