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Developments in the scientific and clinical understanding of autoinflammatory disorders

Lachmann, HJ; Hawkins, PN; (2009) Developments in the scientific and clinical understanding of autoinflammatory disorders. ARTHRITIS RES THER , 11 (1) , Article 212. 10.1186/ar2579. Gold open access

Abstract

The autoinflammatory diseases, also known as periodic fever syndromes, are disorders of innate immunity which can be inherited or acquired and which cause recurrent, self-limiting, seemingly spontaneous episodes of systemic inflammation and fever in the absence of autoantibody production or infection. There has been much recent progress in elucidating their aetiologies and treatment. With the exception of familial Mediterranean fever, which is common in certain populations, autoinflammatory diseases are mostly rare but should not be overlooked in the differential diagnosis of recurrent fevers since DNA diagnosis and effective therapies are available for many of them.

Type: Article
Title: Developments in the scientific and clinical understanding of autoinflammatory disorders
Open access status: An open access publication
DOI: 10.1186/ar2579
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC26882...
Keywords: FAMILIAL MEDITERRANEAN FEVER, RILONACEPT INTERLEUKIN-1 TRAP, SYSTEMIC AA AMYLOIDOSIS, NF-KAPPA-B, PERIODIC FEVER, HYPERIMMUNOGLOBULINEMIA-D, HYPER-IGD, MEFV MUTATIONS, ISOPRENOID BIOSYNTHESIS, HIGH-FREQUENCY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/93092
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