UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Induction of action potentials in cultured slow muscle fibres of the frog.

Cull-Candy, SG; Miledi, R; Uchitel, OD; (1980) Induction of action potentials in cultured slow muscle fibres of the frog. J Physiol , 299 pp. 197-202. 10.1113/jphysiol.1980.sp013119.

Full text not available from this repository.

Abstract

1. Slow muscle fibres of the frog were maintained in a simple organ culture system for up to 28 days at 18 degrees C. Slow fibres cultured for one week resembled innervated fibres in their lack of ability to generate an action potential. 2. By 10 days a few fibres had acquired the action potential mechanism and in muscles cultured for 28 days all slow fibres examined were capable of generating action potentials most of which reached or exceeded 0 mV membrane potential. 3. Slow muscle fibres which were denervated for two weeks in vivo retained their ability to generate overshooting action potentials after 4 weeks of culture. Thus, in the culture system described, slow muscle fibres are capable of developing action potentials and the action potential mechanism in these fibres remains for at least one month in culture.

Type: Article
Title: Induction of action potentials in cultured slow muscle fibres of the frog.
Location: England
DOI: 10.1113/jphysiol.1980.sp013119
Keywords: Action Potentials, Animals, Anura, Muscle Denervation, Muscles, Organ Culture Techniques, Rana temporaria
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/92559
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item