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PROTON SPECTROSCOPY OF THE BRAIN IN HIV-INFECTION - CORRELATION WITH CLINICAL, IMMUNOLOGICAL, AND MR-IMAGING FINDINGS

CHONG, WK; SWEENEY, B; WILKINSON, ID; PALEY, M; HALLCRAGGS, MA; KENDALL, BE; ... HARRISON, MJG; + view all (1993) PROTON SPECTROSCOPY OF THE BRAIN IN HIV-INFECTION - CORRELATION WITH CLINICAL, IMMUNOLOGICAL, AND MR-IMAGING FINDINGS. In: RADIOLOGY. (pp. 119 - 124). RADIOLOGICAL SOC NORTH AMER

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Abstract

Abnormalities at cerebral proton spectroscopy occur in patients with the acquired immunodeficiency syndrome (AIDS). N-acetyl aspartate (NAA) is believed to be a neuronal marker, and neuronal loss is thought to underlie the human immunodeficiency virus (HIV)-associated cognitive/motor complex. The proton spectra in 103 HIV-seropositive patients and 23 control subjects were compared and correlated with clinical, immunologic, and radiologic measures of HIV infection. Significant (P < .05) reductions in the mean NAA/choline (Cho) and NAA/creatine (Cr) ratios were seen in patients with immune suppression and neurologic signs. Significant increases in the Cho/Cr ratios were seen in patients with low CD4 lymphocyte counts and abnormal magnetic resonance (MR) images. Reduced NAA ratios correlated with diffuse but not focal MR imaging abnormalities. Combined MR imaging and spectroscopy provides closer relationships to clinical and immunologic measures of disease than either modality alone. Spectroscopy is an adjunct to MR imaging and augments the value of an MR imaging study.

Type:Proceedings paper
Title:PROTON SPECTROSCOPY OF THE BRAIN IN HIV-INFECTION - CORRELATION WITH CLINICAL, IMMUNOLOGICAL, AND MR-IMAGING FINDINGS
Event:78TH SCIENTIFIC ASSEMBLY OF THE RADIOLOGICAL SOC OF NORTH AMERICA
Location:CHICAGO, IL
Dates:1992-11-22 - 1992-11-27
Keywords:ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), BRAIN, FUNCTION, BRAIN, INFECTION, MAGNETIC RESONANCE (MR), SPECTROSCOPY, ACQUIRED IMMUNODEFICIENCY SYNDROME, NEURONAL LOSS, AIDS, ABNORMALITIES, INDIVIDUALS, VIRUS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Infection and Population Health

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